MMP2 monoclonal antibody, clone SB13a (HRP)
产品名称： MMP2 monoclonal antibody, clone SB13a (HRP)
英文名称： MMP2 monoclonal antibody, clone SB13a (HRP)
产品编号： MAB5893
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against recombinant MMP2.
- Immunogen:
- Recombinant protein corresponding to human MMP2.
- Host:
- Mouse
- Reactivity:
- Human
- Specificity:
- human MMP-2; Does not cross react to human MMP-1, MMP-3 or MMP-9.
- Form:
- Liquid
- Conjugation:
- HRP
- Concentration:
- Lot specific
- Isotype:
- IgG1
- Storage Buffer:
- In PBS, pH 7.4 (50% glycerol)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000-1:4000)
Immunohistochemistry (1:1000-1:2000)
The optimal working dilution should be determined by the end user.
- Publication Reference
- 1.
- Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme.
Knauper V, Will H, Lopez-Otin C, Smith B, Atkinson SJ, Stanton H, Hembry RM, Murphy G.J Biol Chem. 1996 Jul 19;271(29):17124-31.
- 2.
- Matrix metalloproteinases degrade myelin basic protein.
Chandler S, Coates R, Gearing A, Lury J, Wells G, Bone E.Neurosci Lett. 1995 Dec 15;201(3):223-6.
- 3.
- Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2).
Fridman R, Toth M, Pena D, Mobashery S.Cancer Res. 1995 Jun 15;55(12):2548-55.
- Application Image
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunohistochemistry (Frozen sections)
- ELISA
- Entrez GeneID:
- 4313
- Gene Name:
- MMP2
- Gene Alias:
- CLG4,CLG4A,MMP-II,MONA,TBE-1
- Gene Description:
- matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- collagenase type IV-A,matrix metalloproteinase 2,matrix metalloproteinase-II,neutrophil gelatinase
- Interactome
- Related Disease
- Acute Disease
- Adenocarcinoma
- Alzheimer Disease
- Alzheimer disease
- Aortic Aneurysm, Abdominal
- Arthritis, Rheumatoid
- Atherosclerosis
- Atherosclerosis
- Atrial Fibrillation
- Breast cancer
- Breast Neoplasms
- Bronchopulmonary Dysplasia
- Carcinoma
- Carcinoma, Ductal, Breast
- Carcinoma, Hepatocellular
- Carcinoma, Lobular
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- Cardiac Output, Low